Bezafibrate regulates the expression and enzyme activity of 11 -hydroxysteroid dehydrogenase type 1 in murine adipose tissue and 3T3-L1 adipocytes
نویسندگان
چکیده
Shigeru Nakano,* Yoichi Inada,* Hiroaki Masuzaki, Tomohiro Tanaka, Shintaro Yasue, Takako Ishii, Naoki Arai, Ken Ebihara, Kiminori Hosoda, Kazuyasu Maruyama, Yoshinobu Yamazaki, Nobuo Shibata, and Kazuwa Nakao Pharmacology Research Laboratory R&D, and Development Research Department R&D, Kissei Pharmaceutical, Nagano; and Department of Medicine and Clinical Science, Kyoto University Graduate School of Medicine, Kyoto, Japan
منابع مشابه
Bezafibrate regulates the expression and enzyme activity of 11beta-hydroxysteroid dehydrogenase type 1 in murine adipose tissue and 3T3-L1 adipocytes.
A clinically employed antihyperlipidemic drug, bezafibrate, has been characterized as a PPAR(alpha, -gamma, and -delta) pan-agonist in vitro. Recent extended trials have highlighted its antidiabetic properties in humans. However, the underlying molecular mechanism is not fully elucidated. The present study was designed to explore potential regulatory mechanisms of intracellular glucocorticoid r...
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Increased expression and activity of the intracellular glucocorticoid-reactivating enzyme 11 beta-hydroxysteroid dehydrogenase type 1 (11 beta-HSD1) contribute to dysfunction of adipose tissue. Although the pathophysiological role of 11 beta-HSD1 in mature adipocytes has long been investigated, its potential role in preadipocytes still remains obscure. The present study demonstrates that the ex...
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